Data-Driven Solutions for Health & Research
Whether you need expert consulting on immunology research or advanced bioinformatics services for your projects, I provide tailored, data-driven insights to support your breakthroughs. From optimizing research strategies to uncovering actionable data, I'm here to help you make informed decisions and accelerate innovation.
Immunology Consulting
I specialize in working with clients who have developed innovative products and are looking to apply them in real-world settings. I can help you identify the right niche, fine-tune your project focus, and assist with everything from planning to grant writing.
My background is in cancer immunology with a focus on understanding how immune cell contribute to the development of cancers and how they can be harnessed to develop novel therapeutic options. I have years of experience working with a number of different mouse models, organoids and cell lines and techniques like flow cytometry, microscopy and molecular biology.
Whether you need a one-hour consultation to address specific questions or full-scale project management, I’m here to help bring your immunology-related ideas to life.
Sequencing analysis
I have extensive experience in analyzing sequencing data and interpreting it within the context of the underlying biology. As a trained wet-lab scientist who transitioned into bioinformatics, I bring expertise in both areas, which is invaluable for interpreting complex datasets.
My main focus is the analysis of scRNAseq data, but you can find a more detailed list of my skills and experience in the About Me section.
In addition to providing sequencing analysis as a service, I also offer a teaching-oriented approach. I can help clients who have no programming experience develop and understand a pipeline that can be used for any additional data they might generate.
Machine Learning
Machine learning and artifical intelligence has become a large part of our lives, with research being no exception. I can assist with maximizing the impact of your data, including building predictive models or image classification algorithms
I can help you turn your data into valuable insights using advanced machine learning techniques. Get in touch now to discuss the feasibility of your project.
Scientific Writing
As a scientist with over ten years experience, I have strong writing skills, including preparing publications and crafting compelling grant proposals.
Whether you need help refining your manuscript or drafting a competitive grant application, I can support you through every stage of the process.
About Me
Dr Sophie Curio
I am a scientist with over ten years experience in the field of immunology. Having worked in a number of different areas at various universities, including Imperial College London, Harvard Medical School and The University of Queensland, I am an expert in cancer immunology, inflammatory disorders and complex bioinformatics analyses.
Click here to download my CV
Education
- PhD in Immunology, Imperial College London
- Master of Research, Imperial College London
- Bachelor of Science, University of Bonn
Research Expertise
- Cancer Immunology, specifically Liver and Colorectal Cancer
- Inflammatory Disorders, specifically Inflammatory Bowel Disease
- Innate Lymphoid Cell Biology, with a focus on Natural Killer cells and ILC1s
- T Cell Biology, specifically Tumour-infiltrating lymphocytes (TIL)
Technical Skills
- Immunology
- Flow cytometry (up to 30 parameters)
- Microscopy (confocal imaging, multiphoton intravital imaging)
- Molecular biology
- RNA sequencing (single-cell, bulk)
- BCR/TCR sequencing
- Cell culture (primary immune cells, cell lines, organoids)
- Mouse models of disease (liver metastases, intestinal cancer, intestinal inflammation, lung inflammation, intestinal infection)
- Bioinformatics
- Single-cell RNA seq (clustering, trajectory analysis, cell type identification, receptor/ligand interaction, gene regulatory network inference, metabolic activity inference)
- Bulk RNA seq analysis (GSEA, differential gene expression analysis, metabolic pathways)
- BCR/TCR sequencing analysis
- Spatial transcriptomics
- Data Science
- Statistical analysis using Python (including regression analysis, K-means clustering and unsupervised learning using scikit-learn)
- Visualization and presentation of data
- Data mining & integration of independent datasets
- Develop algorithms to generate predictive models
- Image classification using Tensorflow
Publications
Personal Interests
I'm a competition pilot flying national and international competitions.
I love running up mountains! I recently completed my first ultramarathon and use every opportunity to train and increase my endurance.
Projects
Analyzing single-cell RNA sequencing data to understand the development of innate lymphoid cells in the lung
The development of innate lymphoid cell (ILCs), a subset of immune cells found in specific tissues, is still not completely understood. In this project, we set out to understand how ILCs develop in the lung. We found that one specific transcription factor, called GFI1B, regulates the development of specific ILC subsets.
To better understand what is happening on a transcriptional level, we sorted and performed single-cell RNA sequencing on ILCs in the lung. I performed most of the bioinformatics analysis on this project, which included cell type clustering, expression of surface markers and transcription factors, velocity pseudotime and cell cycle analysis.
You can read the paper here.
Australian Climate Influences & Gliding Conditions
There are a number of climate influences that impact soaring conditions in Australia, with the most known one being La Niña/El Niño. Here, I perform multivariate regression analysis to determine which climate influences impact gliding conditions in which state.
Read the blogpost here.
Distance to nearest National Park in Australia
I love good maps! The other day, I came across one showing the distance to the nearest National Park in the US. I thought that it would be interesting to see what a map like that would look like for Australia, the country with the most National Parks in the world.
You can find the code I used for this here.
More projects coming soon!
Contact
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